Reference List
These 474 papers and 2 book sections are included in the Map data.
See also : Map Paper references
Papers
- Akarsu H, Burmeister WP, Petosa C, Petit I, Müller CW, Ruigrok RWH, & Baudin F (2003) Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2). The EMBO journal 22: 4646–4655
- Allen IC, Scull MA, Moore CB, Holl EK, McElvania-TeKippe E, Taxman DJ, Guthrie EH, Pickles RJ, & Ting JP (2009) The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30: 556–565
- Almond JW & Felsenreich V (1982) Phosphorylation of the nucleoprotein of an avian influenza virus. The Journal of general virology 60: 295–305
- Alonso-Caplen F V, Nemeroff ME, Qiu Y, & Krug RM (1992) Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA. Genes & development 6: 255–267
- Amorim MJ, Bruce EA, Read EKC, Foeglein A, Mahen R, Stuart AD, & Digard P (2011) A Rab11- and microtubule-dependent mechanism for cytoplasmic transport of influenza A virus viral RNA. Journal of virology 85: 4143–4156
- Aragón T, De la Luna S, Novoa I, Carrasco L, Ortín J, & Nieto A (2000) Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus. Molecular and cellular biology 20: 6259–6268
- Arcangeletti MC, Pinardi F, Missorini S, De Conto F, Conti G, Portincasa P, Scherrer K, & Chezzi C (1997) Modification of cytoskeleton and prosome networks in relation to protein synthesis in influenza A virus-infected LLC-MK2 cells. Virus research 51: 19–34
- Arrese M & Portela A (1996) Serine 3 is critical for phosphorylation at the N-terminal end of the nucleoprotein of influenza virus A/Victoria/3/75. Journal of virology 70: 3385–3391
- Avalos R, Yu Z, & Nayak D (1997) Association of influenza virus NP and M1 proteins with cellular cytoskeletal elements in influenza virus-infected cells. Journal of virology 71: 2947–2958
- Barbey-Martin C, Gigant B, Bizebard T, Calder LJ, Wharton SA, Skehel JJ, & Knossow M (2002) An antibody that prevents the hemagglutinin low pH fusogenic transition. Virology 294: 70–74
- Barman S, Adhikary L, Chakrabarti AK, Bernas C, Kawaoka Y, & Nayak DP (2004) Role of transmembrane domain and cytoplasmic tail amino acid sequences of influenza a virus neuraminidase in raft association and virus budding. Journal of virology 78: 5258–5269
- Barman S, Ali A, Hui EK, Adhikary L, & Nayak DP (2001) Transport of viral proteins to the apical membranes and interaction of matrix protein with glycoproteins in the assembly of influenza viruses. Virus research 77: 61–69
- Barman S & Nayak DP (2000) Analysis of the transmembrane domain of influenza virus neuraminidase, a type II transmembrane glycoprotein, for apical sorting and raft association. Journal of virology 74: 6538–6545
- Baron W, De Vries E, De Vries H, & Hoekstra D (1999) Protein kinase C prevents oligodendrocyte differentiation: modulation of actin cytoskeleton and cognate polarized membrane traffic. Journal of neurobiology 41: 385–398
- Basu D, Walkiewicz MP, Frieman M, Baric RS, Auble DT, & Engel D a (2009) Novel influenza virus NS1 antagonists block replication and restore innate immune function. Journal of virology 83: 1881–1891
- Baudin F, Petit I, Weissenhorn W, & Ruigrok RW (2001) In vitro dissection of the membrane and RNP binding activities of influenza virus M1 protein. Virology 281: 102–108
- Beigel J & Bray M (2008) Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral research 78: 91–102
- Bergmann M, Garcia-Sastre A, Carnero E, Pehamberger H, Wolff K, Palese P, & Muster T (2000) Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. Journal of virology 74: 6203–6206
- Bertram S, Glowacka I, Blazejewska P, Soilleux E, Allen P, Danisch S, Steffen I, Choi S-Y, Park Y, Schneider H, Schughart K, & Pöhlmann S (2010a) TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells. Journal of virology 84: 10016–10025
- Bertram S, Glowacka I, Steffen I, Kühl A, & Pöhlmann S (2010b) Novel insights into proteolytic cleavage of influenza virus hemagglutinin. Reviews in Medical Virology 20: 298–310
- Bier K, York A, & Fodor E (2011) Cellular cap-binding proteins associate with influenza virus mRNAs. The Journal of general virology 92: 1627–1634
- Birnkrant D & Cox E (2009) The Emergency Use Authorization of peramivir for treatment of 2009 H1N1 influenza. The New England journal of medicine 361: 2204–2207
- Blaas D, Patzelt E, & Kuechler E (1982a) Cap-recognizing protein of influenza virus. Virology 116: 339–348
- Blaas D, Patzelt E, & Kuechler E (1982b) Identification of the cap binding protein of influenza virus. Nucleic acids research 10: 4803–4812
- Boulo S, Akarsu H, Ruigrok RWH, & Baudin F (2007) Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes. Virus research 124: 12–21
- Braam J, Ulmanen I, & Krug RM (1983) Molecular model of a eucaryotic transcription complex: functions and movements of influenza P proteins during capped RNA-primed transcription. Cell 34: 609–618
- Brandt S, Raffetseder U, Djudjaj S, Schreiter A, Kadereit B, Michele M, Pabst M, Zhu C, & Mertens PR (2012) Cold shock Y-box protein-1 participates in signaling circuits with auto-regulatory activities. European journal of cell biology 91: 464–471
- Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, Van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, & Elledge SJ (2009) The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 139: 1243–1254
- Brooks MJ, Burtseva EI, Ellery PJ, Marsh GA, Lew AM, Slepushkin AN, Crowe SM, & Tannock GA (2012) Antiviral activity of arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions. Journal of medical virology 84: 170–181
- Bruce EA, Abbink TE, Wise HM, Rollason R, Galao RP, Banting G, Neil SJ, & Digard P (2012) Release of filamentous and spherical influenza A virus is not restricted by tetherin. The Journal of general virology 93: 963–969
- Bruce EA, Digard P, & Stuart AD (2010) The Rab11 pathway is required for influenza A virus budding and filament formation. Journal of virology 84: 5848–5859
- Bui M, Myers JE, & Whittaker GR (2002) Nucleo-cytoplasmic localization of influenza virus nucleoprotein depends on cell density and phosphorylation. Virus research 84: 37–44
- Bui M, Whittaker G, & Helenius A (1996) Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins. Journal of virology 70: 8391–8401
- Bui M, Wills EG, Helenius A, & Whittaker GR (2000) Role of the influenza virus M1 protein in nuclear export of viral ribonucleoproteins. Journal of virology 74: 1781–1786
- Bullido R, Gómez-Puertas P, Albo C, & Portela A (2000) Several protein regions contribute to determine the nuclear and cytoplasmic localization of the influenza A virus nucleoprotein. The Journal of general virology 81: 135–142
- Burgui I, Aragón T, Ortín J, & Nieto A (2003) PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes. Journal of General Virology 84: 3263–3274
- Burgui I, Yángüez E, Sonenberg N, & Nieto A (2007) Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation? Journal of virology 81: 12427–12438
- Böttcher E, Matrosovich T, Beyerle M, Klenk H-D, Garten W, & Matrosovich M (2006) Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. Journal of virology 80: 9896–9898
- Böttcher-Friebertshäuser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, Uhlendorff J, Steinmetzer T, Klenk HD, & Garten W (2010) Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors. Journal of virology 84: 5605–5614
- Cao S, Liu X, Yu M, Li J, Jia X, Bi Y, Sun L, Gao GF, & Liu W (2012) A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication. Journal of virology 86: 4883–4891
- Carlson CM, Turpin EA, Moser LA, O’Brien KB, Cline TD, Jones JC, Tumpey TM, Katz JM, Kelley LA, Gauldie J, & Schultz-Cherry S (2010) Transforming growth factor-β: activation by neuraminidase and role in highly pathogenic H5N1 influenza pathogenesis. PLoS pathogens 6: e1001136
- Carrasco M, Amorim MJ, & Digard P (2004) Lipid raft-dependent targeting of the influenza A virus nucleoprotein to the apical plasma membrane. Traffic (Copenhagen, Denmark) 5: 979–992
- Chan RWY, Chan MCW, Wong ACN, Karamanska R, Dell A, Haslam SM, Sihoe ADL, Chui WH, Triana-Baltzer G, Li Q, Peiris JSM, Fang F, & Nicholls JM (2009) DAS181 inhibits H5N1 influenza virus infection of human lung tissues. Antimicrobial agents and chemotherapy 53: 3935–3941
- Chan-Tack KM, Murray JS, & Birnkrant DB (2009) Use of ribavirin to treat influenza. The New England journal of medicine 361: 1713–1714
- Chanturiya A, Basañez G, Schubert U, Henklein P, Yewdell J, & Zimmerberg J (2004) PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes. Journal of virology 78: 6304–6312
- Chen BJ, Leser GP, Morita E, & Lamb RA (2007) Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles. Journal of virology 81: 7111–7123
- Chen C & Zhuang X (2008) Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proceedings of the National Academy of Sciences of the United States of America 105: 11790–11795
- Chen CJ, Chen GW, Wang CH, Huang CH, Wang YC, & Shih SR (2010) Differential localization and function of PB1-F2 derived from different strains of influenza A virus. Journal of virology 84: 10051–10062
- Chen W, Calvo P, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O’Neill R, Schickli J, Palese P, Henklein P, Bennink J, & Yewdell J (2001) A novel influenza A virus mitochondrial protein that induces cell death. Nature Medicine 7: 1306–1312
- Chen Z & Krug RM (2000) Selective nuclear export of viral mRNAs in influenza-virus-infected cells. Trends in microbiology 8: 376–383
- Chen Z, Li Y, & Krug RM (1999) Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3’-end processing machinery. The EMBO journal 18: 2273–2283
- Cheng A, Wong SM, & Yuan YA (2009) Structural basis for dsRNA recognition by NS1 protein of influenza A virus. Cell research 19: 187–195
- De Clercq E (2006) Antiviral agents active against influenza A viruses. Nature reviews. Drug discovery 5: 1015–1025
- De Clercq E & Neyts J (2007) Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention. Trends in pharmacological sciences 28: 280–285
- Conenello GM, Zamarin D, Perrone LA, Tumpey T, & Palese P (2007) A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence. PLoS pathogens 3: 1414–1421
- Connor RJ, Kawaoka Y, Webster RG, & Paulson JC (1994) Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates. Virology 205: 17–23
- Cros JF, García-Sastre A, & Palese P (2005) An Unconventional NLS is Critical for the Nuclear Import of the Influenza A Virus Nucleoprotein and Ribonucleoprotein. Traffic (Copenhagen, Denmark) 6: 205–213
- Cros JF & Palese P (2003) Trafficking of viral genomic RNA into and out of the nucleus: influenza, Thogoto and Borna disease viruses. Virus Research 95: 3–12
- Cross KJ, Langley WA, Russell RJ, Skehel JJ, & Steinhauer DA (2009) Composition and functions of the influenza fusion peptide. Protein and peptide letters 16: 766–778
- Daniels R, Kurowski B, Johnson AE, & Hebert DN (2003) N-linked glycans direct the cotranslational folding pathway of influenza hemagglutinin. Molecular cell 11: 79–90
- Danishuddin M, Khan SN, & Khan AU (2010) Molecular interactions between mitochondrial membrane proteins and the C-terminal domain of PB1-F2: an in silico approach. Journal of molecular modeling 16: 535–541
- Deng T, Engelhardt OG, Thomas B, Akoulitchev A V, Brownlee GG, & Fodor E (2006) Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex. Journal of virology 80: 11911–11919
- Deng T, Sharps J, Fodor E, & Brownlee GG (2005) In vitro assembly of PB2 with a PB1-PA dimer supports a new model of assembly of influenza A virus polymerase subunits into a functional trimeric complex. Journal of virology 79: 8669–8674
- Dias A, Bouvier D, Crépin T, McCarthy A a, Hart DJ, Baudin F, Cusack S, & Ruigrok RWH (2009) The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature 458: 914–918
- Diebold SS, Kaisho T, Hemmi H, Akira S, & Reis e Sousa C (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (New York, N.Y.) 303: 1529–1531
- Digard P, Elton D, Bishop K, Medcalf E, Weeds A, & Pope B (1999) Modulation of nuclear localization of the influenza virus nucleoprotein through interaction with actin filaments. Journal of virology 73: 2222–2231
- Dittmann J, Stertz S, Grimm D, Steel J, García-Sastre A, Haller O, & Kochs G (2008) Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase. Journal of virology 82: 3624–3631
- Doms R, Lamb R, Rose J, & Helenius A (1993) Folding and Assembly of Viral Membrane Proteins. Virology 193: 545–562
- Donelan NR, Basler CF, & García-Sastre A (2003) A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice. Journal of virology 77: 13257–13266
- Dreux M & Chisari F V (2010) Viruses and the autophagy machinery. Cell cycle (Georgetown, Tex.) 9: 1295–1307
- Droebner K, Pleschka S, Ludwig S, & Planz O (2011) Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral research 92: 195–203
- Ehrhardt C & Ludwig S (2009) A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway. Cellular microbiology 11: 863–871
- Ehrhardt C, Marjuki H, Wolff T, Nürnberg B, Planz O, Pleschka S, & Ludwig S (2006) Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence. Cellular microbiology 8: 1336–1348
- Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, & Ludwig S (2010) Interplay between influenza A virus and the innate immune signaling. Microbes and infection / Institut Pasteur 12: 81–87
- Ehrhardt C, Wolff T, & Ludwig S (2007a) Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses. Journal of virology 81: 12097–12100
- Ehrhardt C, Wolff T, Pleschka S, Planz O, Beermann W, Bode JG, Schmolke M, & Ludwig S (2007b) Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. Journal of virology 81: 3058–3067
- Eierhoff T, Hrincius ER, Rescher U, Ludwig S, & Ehrhardt C (2010) The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. PLoS pathogens 6: e1001099
- Eisfeld AJ, Kawakami E, Watanabe T, Neumann G, & Kawaoka Y (2011a) RAB11A is essential for transport of the influenza virus genome to the plasma membrane. Journal of virology 85: 6117–6126
- Eisfeld AJ, Neumann G, & Kawaoka Y (2011b) Human immunodeficiency virus rev-binding protein is essential for influenza a virus replication and promotes genome trafficking in late-stage infection. Journal of virology 85: 9588–9598
- Ekiert DC, Bhabha G, Elsliger M-A, Friesen RHE, Jongeneelen M, Throsby M, Goudsmit J, & Wilson IA (2009) Antibody recognition of a highly conserved influenza virus epitope. Science (New York, N.Y.) 324: 246–251
- Ekinci FY & Barefoot SF (2006) Fed-batch enhancement of jenseniin G, a bacteriocin produced by Propionibacterium thoenii (jensenii) P126. Food microbiology 23: 325–330
- Elton D, Simpson-holley M, Archer K, Hallam R, Mccauley J, Digard P, Medcalf LIZ, & Cauley JMC (2001) Interaction of the Influenza Virus Nucleoprotein with the Cellular CRM1-Mediated Nuclear Export Pathway. Journal of virology 75: 408–419
- Enami M & Enami K (1996) Influenza virus hemagglutinin and neuraminidase glycoproteins stimulate the membrane association of the matrix protein. Journal of virology 70: 6653–6657
- Engelhardt OG & Fodor E (2006) Functional association between viral and cellular transcription during influenza virus infection. Reviews in medical virology 16: 329–345
- Engelhardt OG, Smith M, & Fodor E (2005) Association of the Influenza A Virus RNA-Dependent RNA Polymerase with Cellular RNA Polymerase II. Journal of virology 79: 5812–5818
- Eyers S, Weatherall M, Shirtcliffe P, Perrin K, & Beasley R (2010) The effect on mortality of antipyretics in the treatment of influenza infection: systematic review and meta-analysis. Journal of the Royal Society of Medicine 103: 403–411
- Falcón AM, Fortes P, Marión RM, Beloso A, & Ortín J (1999) Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. Nucleic acids research 27: 2241–2247
- Falcón AM, Marión RM, Zürcher T, Gómez P, Portela A, Nieto A, & Ortín J (2004) Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein. Journal of virology 78: 3880–3888
- Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen L-M, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, & Brass AL (2011) IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry. PLoS Pathogens 7: e1002337
- Fiore AE, Fry A, Shay D, Gubareva L, Bresee JS, & Uyeki TM (2011) Antiviral agents for the treatment and chemoprophylaxis of influenza --- recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control 60: 1–24
- Fitzgerald KA (2011) The interferon inducible gene: Viperin. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 31: 131–135
- Fodor E & Smith M (2004) The PA subunit is required for efficient nuclear accumulation of the PB1 subunit of the influenza A virus RNA polymerase complex. Journal of virology 78: 9144–9153
- Fortes P, Beloso A, & Ortín J (1994) Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. The EMBO journal 13: 704–712
- Fulda S, Galluzzi L, & Kroemer G (2010) Targeting mitochondria for cancer therapy. Nature reviews. Drug discovery 9: 447–464
- Furuta Y, Takahashi K, Kuno-Maekawa M, Sangawa H, Uehara S, Kozaki K, Nomura N, Egawa H, & Shiraki K (2005) Mechanism of action of T-705 against influenza virus. Antimicrobial agents and chemotherapy 49: 981–986
- Gack MU, Albrecht RA, Urano T, Inn KS, Huang IC, Carnero E, Farzan M, Inoue S, Jung JU, & García-Sastre A (2009) Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell host & microbe 5: 439–449
- Gack MU, Nistal-Villán E, Inn KS, García-Sastre A, & Jung JU (2010) Phosphorylation-mediated negative regulation of RIG-I antiviral activity. Journal of virology 84: 3220–3229
- Gale M, Blakely CM, Darveau A, Romano PR, Korth MJ, & Katze MG (2002) P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress. Biochemistry 41: 11878–11887
- Gambaryan AS, Tuzikov AB, Piskarev VE, Yamnikova SS, Lvov DK, Robertson JS, Bovin N V, & Matrosovich MN (1997) Specification of receptor-binding phenotypes of influenza virus isolates from different hosts using synthetic sialylglycopolymers: non-egg-adapted human H1 and H3 influenza A and influenza B viruses share a common high binding affinity for 6’-sialyl(N-ace. Virology 232: 345–350
- Gannagé M, Dormann D, Albrecht R, Dengjel J, Torossi T, Rämer PC, Lee M, Strowig T, Arrey F, Conenello G, Pypaert M, Andersen J, García-Sastre A, & Münz C (2009) Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell host & microbe 6: 367–380
- Gannagé M, Rämer PC, & Münz C (2010) Targeting Beclin 1 for viral subversion of macroautophagy. Autophagy 6: 166–167
- Gao S, Von der Malsburg A, Dick A, Faelber K, Schröder GF, Haller O, Kochs G, & Daumke O (2011) Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function. Immunity 35: 514–525
- Garaigorta U & Ortín J (2007) Mutation analysis of a recombinant NS replicon shows that influenza virus NS1 protein blocks the splicing and nucleo-cytoplasmic transport of its own viral mRNA. Nucleic acids research 35: 4573–4582
- García-Sastre A (2001) Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. Virology 279: 375–384
- García-Sastre A (2011) Induction and evasion of type I interferon responses by influenza viruses. Virus research 162: 12–18
- Garrido C, Galluzzi L, Brunet M, Puig P, Didelot C, & Kroemer G (2006) Mechanisms of cytochrome c release from mitochondria. Cell death and differentiation 13: 1423–1433
- Geiler J, Michaelis M, Sithisarn P, & Cinatl J (2011) Comparison of pro-inflammatory cytokine expression and cellular signal transduction in human macrophages infected with different influenza A viruses. Medical microbiology and immunology 200: 53–60
- Gerritz SW, Cianci C, Kim S, Pearce BC, Deminie C, Discotto L, McAuliffe B, Minassian BF, Shi S, Zhu S, Zhai W, Pendri A, Li G, Poss MA, Edavettal S, McDonnell PA, Lewis HA, Maskos K, Mörtl M, Kiefersauer R, et al (2011) Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers. Proceedings of the National Academy of Sciences of the United States of America 108: 15366–15371
- Gething M, McCammon K, & Sambrook J (1986) Expression of wild-type and mutant forms of influenza hemagglutinin: the role of folding in intracellular transport. Cell 46: 939–950
- Gibbs JS, Malide D, Hornung F, Bennink JR, & Yewdell JW (2003) The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function. Journal of virology 77: 7214–7224
- Le Goffic R, Arshad MI, Rauch M, L’helgoualc'h A, Delmas B, Piquet-Pellorce C, & Samson M (2011) Influenza Virus Infection Induces IL-33 in Mouse Lungs. American journal of respiratory cell and molecular biology 45: 1125–1132
- Le Goffic R, Balloy V, Lagranderie M, Alexopoulou L, Escriou N, Flavell R, Chignard M, & Si-Tahar M (2006) Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS pathogens 2: e53
- Le Goffic R, Pothlichet J, Vitour D, Fujita T, Meurs E, Chignard M, & Si-Tahar M (2007) Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. Journal of immunology (Baltimore, Md. : 1950) 178: 3368–3372
- Golebiewski L, Liu H, Javier RT, & Rice AP (2011) The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions. Journal of virology 85: 10639–10648
- Goodman AG, Smith JA, Balachandran S, Perwitasari O, Proll SC, Thomas MJ, Korth MJ, Barber GN, Schiff LA, & Katze MG (2007) The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism. Journal of virology 81: 2221–2230
- Gorai T, Goto H, Noda T, Watanabe T, Kozuka-Hata H, Oyama M, Takano R, Neumann G, Watanabe S, & Kawaoka Y (2012) F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding. Proceedings of the National Academy of Sciences of the United States of America 109: 4615–4620
- Graef KM, Vreede FT, Lau YF, McCall AW, Carr SM, Subbarao K, & Fodor E (2010) The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon. Journal of virology 84: 8433–8445
- Grantham ML, Wu WH, Lalime EN, Lorenzo ME, Klein SL, & Pekosz A (2009) Palmitoylation of the influenza A virus M2 protein is not required for virus replication in vitro but contributes to virus virulence. Journal of virology 83: 8655–8661
- Greenspan D, Krystal M, Nakada S, Arnheiter H, Lyles DS, & Palese P (1985) Expression of influenza virus NS2 nonstructural protein in bacteria and localization of NS2 in infected eucaryotic cells. Journal of virology 54: 833–843
- Greenspan D, Palese P, & Krystal M (1988) Two nuclear location signals in the influenza virus NS1 nonstructural protein. Journal of virology 62: 3020–3026
- Gregoriades A, Guzman G, & Paoletti E (1990) The phosphorylation of the integral membrane (M1) protein of influenza virus. Virus research 16: 27–41
- Griffin JA & Compans RW (1979) Effect of cytochalasin B on the maturation of enveloped viruses. The Journal of experimental medicine 150: 379–391
- Guan Z, Liu D, Mi S, Zhang J, Ye Q, Wang M, Gao GF, & Yan J (2010) Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway. Protein & cell 1: 944–955
- Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M, & Si-Tahar M (2005) Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. The Journal of biological chemistry 280: 5571–5580
- Hai R, Martínez-Sobrido L, Fraser KA, Ayllon J, García-Sastre A, & Palese P (2008) Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach. Journal of virology 82: 10580–10590
- Hale BG, Batty IH, Downes CP, & Randall RE (2008a) Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation. The Journal of biological chemistry 283: 1372–1380
- Hale BG, Jackson D, Chen Y-H, Lamb R a, & Randall RE (2006) Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proceedings of the National Academy of Sciences of the United States of America 103: 14194–14199
- Hale BG, Kerry PS, Jackson D, Precious BL, Gray A, Killip MJ, Randall RE, & Russell RJ (2010) Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. Proceedings of the National Academy of Sciences of the United States of America 107: 1954–1959
- Hale BG, Knebel A, Botting CH, Galloway CS, Precious BL, Jackson D, Elliott RM, & Randall RE (2009) CDK/ERK-mediated phosphorylation of the human influenza A virus NS1 protein at threonine-215. Virology 383: 6–11
- Hale BG & Randall RE (2007) PI3K signalling during influenza A virus infections. Biochemical Society transactions 35: 186–187
Hale BG, Randall RE, Ortín J, & Jackson D (2008b) The multifunctional NS1 protein of influenza A viruses. The Journal of general virology 89: 2359–2376
- Haller O, Arnheiter H, Lindenmann J, & Gresser I (1980) Host gene influences sensitivity to interferon action selectively for influenza virus. Nature 283: 660–662
- Haller O & Kochs G (2002) Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity. Traffic (Copenhagen, Denmark) 3: 710–717
- Haller O, Staeheli P, & Kochs G (2009) Protective role of interferon-induced Mx GTPases against influenza viruses. Revue scientifique et technique (International Office of Epizootics) 28: 219–231
- Haller O, Stertz S, & Kochs G (2007) The Mx GTPase family of interferon-induced antiviral proteins. Microbes and infection / Institut Pasteur 9: 1636–1643
- Hammond C, Braakman I, & Helenius A (1994) Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control. Proceedings of the National Academy of Sciences of the United States of America 91: 913–917
- Hastings J, Selnick H, Wolanski B, & Tomassini J (1996) Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors. Antimicrobial agents and chemotherapy 40: 1304–1307
- Hatada E, Saito S, & Fukuda R (1999) Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells. Journal of virology 73: 2425–2433
- Hausmann J, Kretzschmar E, Garten W, & Klenk H (1997) Biosynthesis, intracellular transport and enzymatic activity of an avian influenza A virus neuraminidase: role of unpaired cysteines and individual oligosaccharides. The Journal of general virology 78: 3233–3245
- He C & Levine B (2010) The Beclin 1 interactome. Current opinion in cell biology 22: 140–149
- Hebert DN, Foellmer B, & Helenius A (1995) Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum. Cell 81: 425–433
- Hebert DN, Foellmer B, & Helenius A (1996) Calnexin and calreticulin promote folding, delay oligomerization and suppress degradation of influenza hemagglutinin in microsomes. The EMBO journal 15: 2961–2968
- Heikkinen LS, Kazlauskas A, Melén K, Wagner R, Ziegler T, Julkunen I, & Saksela K (2008) Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling. The Journal of biological chemistry 283: 5719–5727
- Heino S, Lusa S, Somerharju P, Ehnholm C, Olkkonen VM, & Ikonen E (2000) Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface. Proceedings of the National Academy of Sciences of the United States of America 97: 8375–8380
- Helenius A (1992) Unpacking the Incoming Influenza Virus Minireview. Cell 69: 577–578
- Henkel M, Mitzner D, Henklein P, Meyer-Almes F-J, Moroni A, Difrancesco ML, Henkes LM, Kreim M, Kast SM, Schubert U, & Thiel G (2010) The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel. PloS one 5: e11112
- Hernandez JE, Adiga R, Armstrong R, Bazan J, Bonilla H, Bradley J, Dretler R, Ison MG, Mangino JE, Maroushek S, Shetty AK, Wald A, Ziebold C, Elder J, Hollister AS, & Sheridan W (2011) Clinical experience in adults and children treated with intravenous peramivir for 2009 influenza A (H1N1) under an Emergency IND program in the United States. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 52: 695–706
- Herold S, Steinmueller M, Von Wulffen W, Cakarova L, Pinto R, Pleschka S, Mack M, Kuziel WA, Corazza N, Brunner T, Seeger W, & Lohmeyer J (2008) Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand. The Journal of experimental medicine 205: 3065–3077
- Heynisch B, Frensing T, Heinze K, Seitz C, Genzel Y, & Reichl U (2010) Differential activation of host cell signalling pathways through infection with two variants of influenza A/Puerto Rico/8/34 (H1N1) in MDCK cells. Vaccine 28: 8210–8218
- Hinton A, Bond S, & Forgac M (2009) V-ATPase functions in normal and disease processes. Pflügers Archiv : European journal of physiology 457: 589–598
- Hirayama E, Atagi H, Hiraki A, & Kim J (2004) Heat Shock Protein 70 Is Related to Thermal Inhibition of Nuclear Export of the Influenza Virus Ribonucleoprotein Complex. Journal of virology 78: 1263–1270
- Holsinger LJ, Shaughnessy MA, Micko A, Pinto LH, & Lamb RA (1995) Analysis of the posttranslational modifications of the influenza virus M2 protein. Journal of virology 69: 1219–1225
- Honda A, Okamoto T, & Ishihama A (2007) Host factor Ebp1: selective inhibitor of influenza virus transcriptase. Genes to cells : devoted to molecular & cellular mechanisms 12: 133–142
- Horgan CP & McCaffrey MW (2009) The dynamic Rab11-FIPs. Biochemical Society transactions 37: 1032–1036
- Horimoto T & Kawaoka Y (1994) Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus. Journal of virology 68: 3120–3128
- Hosoya M, Matsuyama S, Baba M, Suzuki H, & Shigeta S (1992) Effects of Protease Inhibitors on Replication of Various Myxoviruses. Antimicrobial agents and chemotherapy 36: 1432–1436
- Hrincius ER, Dierkes R, Anhlan D, Wixler V, Ludwig S, & Ehrhardt C (2011) Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production. Cellular microbiology 13: 1907–1919
- Hsiang T-Y, Zhou L, & Krug RM (2012) Roles of the phosphorylation of specific serines and threonines in the NS1 protein of human influenza A viruses. Journal of virology 86: 10370–10376
- Huang X, Liu T, Muller J, Levandowski RA, & Ye Z (2001) Effect of influenza virus matrix protein and viral RNA on ribonucleoprotein formation and nuclear export. Virology 287: 405–416
Huang Y, Gattoni R, Stévenin J, & Steitz JA (2003) SR Splicing Factors Serve as Adapter Proteins for TAP-Dependent mRNA Export. Molecular cell 11: 837–843
- Huarte M, Sanz-ezquerro JJ, Roncal F, Ortín J, & Nieto A (2001) PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. Journal of virology 75: 8597–8604
- Huet S, Avilov S V, Ferbitz L, Daigle N, Cusack S, & Ellenberg J (2010) Nuclear import and assembly of influenza A virus RNA polymerase studied in live cells by fluorescence cross-correlation spectroscopy. Journal of virology 84: 1254–1264
- Hui EK & Nayak DP (2001) Role of ATP in influenza virus budding. Virology 290: 329–341
- Hui EK-W & Nayak DP (2002) Role of G protein and protein kinase signalling in influenza virus budding in MDCK cells. The Journal of general virology 83: 3055–3066
- Husain M & Harrod KS (2011) Enhanced acetylation of alpha-tubulin in influenza A virus infected epithelial cells. FEBS letters 585: 128–132
- Hutchinson EC, Denham EM, Thomas B, Trudgian DC, Hester SS, Ridlova G, York A, Turrell L, & Fodor E (2012) Mapping the Phosphoproteome of Influenza A and B Viruses by Mass Spectrometry. PLoS Pathogens 8: e1002993
- Hutchinson EC, Orr OE, Man Liu S, Engelhardt OG, & Fodor E (2011) Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5. The Journal of general virology 92: 1859–1869
- Hutten S & Kehlenbach RH (2007) CRM1-mediated nuclear export: to the pore and beyond. Trends in cell biology 17: 193–201
Ichinohe T, Lee HK, Ogura Y, Flavell R, & Iwasaki A (2009) Inflammasome recognition of influenza virus is essential for adaptive immune responses. The Journal of experimental medicine 206: 79–87
- Ichinohe T, Pang IK, & Iwasaki A (2010) Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nature immunology 11: 404–410
- Iglesias N & Stutz F (2008) Regulation of mRNP dynamics along the export pathway. FEBS letters 582: 1987–1996
- Ito T & Kawaoka Y (2000) Host-range barrier of influenza A viruses. Veterinary microbiology 74: 71–75
- Von Itzstein M, Wu WY, Kok GB, Pegg MS, Dyason JC, Jin B, Van Phan T, Smythe ML, White HF, & Oliver SW (1993) Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363: 418–423
- Iverson AR, Boyd KL, McAuley JL, Plano LR, Hart ME, & McCullers JA (2011) Influenza virus primes mice for pneumonia from Staphylococcus aureus. The Journal of infectious diseases 203: 880–888
- Iwai A, Shiozaki T, Kawai T, Akira S, Kawaoka Y, Takada A, Kida H, & Miyazaki T (2010) Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1. The Journal of biological chemistry 285: 32064–32074
- Iwatsuki-Horimoto K, Horimoto T, Fujii Y, & Kawaoka Y (2004) Generation of influenza A virus NS2 (NEP) mutants with an altered nuclear export signal sequence. Journal of virology 78: 10149–10155
- Iwatsuki-Horimoto K, Horimoto T, Noda T, Kiso M, Maeda J, Watanabe S, Muramoto Y, Fujii K, & Kawaoka Y (2006) The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly. Journal of virology 80: 5233–5240
- Jablonski JJ, Basu D, Engel DA, & Geysen HM (2012) Design, synthesis, and evaluation of novel small molecule inhibitors of the influenza virus protein NS1. Bioorganic & medicinal chemistry 20: 487–497
- Jackson D, Hossain MJ, Hickman D, Perez DR, & Lamb RA (2008) A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proceedings of the National Academy of Sciences of the United States of America 105: 4381–4386
- Javier RT & Rice AP (2011) Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses. Journal of virology 85: 11544–11556
- Jefferies KC, Cipriano DJ, & Forgac M (2008) Function, structure and regulation of the vacuolar (H+)-ATPases. Archives of biochemistry and biophysics 476: 33–42
- Jia D, Rahbar R, Chan RW, Lee SM, Chan MC, Wang BX, Baker DP, Sun B, Peiris J, Nicholls JM, & Fish EN (2010) Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. PloS one 5: e13927
- Jiang X & Chen ZJ (2011) Viperin links lipid bodies to immune defense. Immunity 34: 285–287
- Jones IM, Reay PA, & Philpott KL (1986) Nuclear location of all three influenza polymerase proteins and a nuclear signal in polymerase PB2. The EMBO journal 5: 2371–2376
- Kang R, Zeh HJ, Lotze MT, & Tang D (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell death and differentiation 18: 571–580
- Kao RY, Yang D, Lau L-S, Tsui WHW, Hu L, Dai J, Chan M-P, Chan C-M, Wang P, Zheng B-J, Sun J, Huang J-D, Madar J, Chen G, Chen H, Guan Y, & Yuen K-Y (2010) Identification of influenza A nucleoprotein as an antiviral target. Nature biotechnology 28: 600–605
- Kash JC, Cunningham DM, Smit MW, Park Y, Fritz D, Wilusz J, & Katze MG (2002) Selective Translation of Eukaryotic mRNAs : Functional Molecular Analysis of GRSF-1 , a Positive Regulator of Influenza Virus Protein Synthesis. Journal of virology 76: 10417–10426
- Kash JC, Goodman AG, Korth MJ, & Katze MG (2006) Hijacking of the host-cell response and translational control during influenza virus infection. Virus research 119: 111–120
- Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh C-S, Reis e Sousa C, Matsuura Y, Fujita T, & Akira S (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441: 101–105
- Katze MG (1992) The war against the interferon-induced dsRNA-activated protein kinase: can viruses win? Journal of interferon research 12: 241–248
- Katze MG, Chen YT, & Krug RM (1984) Nuclear-cytoplasmic transport and VAI RNA-independent translation of influenza viral messenger RNAs in late adenovirus-infected cells. Cell 37: 483–490
- Katze MG, DeCorato D, & Krug RM (1986a) Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirus. Journal of virology 60: 1027–1039
- Katze MG, Detjen BM, Safer B, & Krug RM (1986b) Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs. Molecular and cellular biology 6: 1741–1750
- Kawaguchi A, Matsumoto K, & Nagata K (2012) YB-1 functions as a porter to lead influenza virus ribonucleoprotein complexes to microtubules. Journal of virology 86: 11086–11095
- Kawaguchi A & Nagata K (2007) De novo replication of the influenza virus RNA genome is regulated by DNA replicative helicase, MCM. The EMBO journal 26: 4566–4575
- Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, & Akira S (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nature immunology 6: 981–988
- Khor R, Mcelroy LJ, & Whittaker R (2003) The Ubiquitin-Vacuolar Protein Sorting System is Selectively Required During Entry of Influenza Virus into Host Cells. Traffic 4: 857–868
- Kido H, Yokogoshi Y, Sakai K, Tashiro M, Kishino Y, Fukutomi A, & Katunuma N (1992) Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein. The Journal of biological chemistry 267: 13573–13579
- Kiso M, Kubo S, Ozawa M, Le QM, Nidom CA, Yamashita M, & Kawaoka Y (2010a) Efficacy of the new neuraminidase inhibitor CS-8958 against H5N1 influenza viruses. PLoS pathogens 6: e1000786
- Kiso M, Takahashi K, Sakai-Tagawa Y, Shinya K, Sakabe S, Le QM, Ozawa M, Furuta Y, & Kawaoka Y (2010b) T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proceedings of the National Academy of Sciences of the United States of America 107: 882–887
- Kistner O, Müller K, & Scholtissek C (1989) Differential phosphorylation of the nucleoprotein of influenza A viruses. The Journal of general virology 70 ( Pt 9): 2421–2431
- Klenk H-D, Wagner R, Heuer D, & Wolff T (2002) Importance of hemagglutinin glycosylation for the biological functions of influenza virus. Virus research 82: 73–75
- Knossow M, Gaudier M, Douglas A, Barrère B, Bizebard T, Barbey C, Gigant B, & Skehel JJ (2002) Mechanism of neutralization of influenza virus infectivity by antibodies. Virology 302: 294–298
- Krumbholz A, Philipps A, Oehring H, Schwarzer K, Eitner A, Wutzler P, & Zell R (2011) Current knowledge on PB1-F2 of influenza A viruses. Medical microbiology and immunology 200: 69–75
- Kudo N, Matsumori N, Taoka H, Fujiwara D, Schreiner EP, Wolff B, Yoshida M, & Horinouchi S (1999) Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proceedings of the National Academy of Sciences of the United States of America 96: 9112–9117
- Kujime K, Hashimoto S, Gon Y, Shimizu K, & Horie T (2000) p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells. Journal of immunology (Baltimore, Md. : 1950) 164: 3222–3228
- Kumar N, Liang Y, Parslow TG, & Liang Y (2011) Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. Journal of virology 85: 2818–2827
- Kundu A, Avalos RT, Sanderson CM, & Nayak DP (1996) Transmembrane domain of influenza virus neuraminidase, a type II protein, possesses an apical sorting signal in polarized MDCK cells. Journal of virology 70: 6508–6515
- Kunzelmann K, Beesley AH, King NJ, Karupiah G, Young JA, & Cook DI (2000) Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia. Proceedings of the National Academy of Sciences of the United States of America 97: 10282–10287
- Lafont F, Burkhardt J, & Simons K (1994) Involvement of microtubule motors in basolateral and apical transport in kidney cells. Nature 372: 801–803
- Lakadamyali M, Rust MJ, & Zhuang X (2004) Endocytosis of influenza viruses. Microbes and infection / Institut Pasteur 6: 929–936
- Lakadamyali M, Rust MJ, & Zhuang X (2006) Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124: 997–1009
- Landeras-Bueno S, Jorba N, Pérez-Cidoncha M, & Ortín J (2011) The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. PLoS pathogens 7: e1002397
- Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos N V, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, García-Sastre A, Leib DA, Pekosz A, Knobeloch K-P, Horak I, & Virgin HW (2007) IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proceedings of the National Academy of Sciences of the United States of America 104: 1371–1376
- Leser GP & Lamb RA (2005) Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteins. Virology 342: 215–227
- Li S, Min J-Y, Krug RM, & Sen GC (2006) Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology 349: 13–21
- Li S, Schulman J, Itamura S, & Palese P (1993) Glycosylation of neuraminidase determines the neurovirulence of influenza A/WSN/33 virus. Journal of virology 67: 6667–6673
- Li X & Palese P (1994) Characterization of the polyadenylation signal of influenza virus RNA. Journal of virology 68: 1245–1249
- Li Y, Anderson DH, Liu Q, & Zhou Y (2008) Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity. The Journal of biological chemistry 283: 23397–23409
- Li Y, Chen ZY, Wang W, Baker C, & Krug R (2001) The 3’-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo. RNA 7: 920–931
- Liao TL, Wu CY, Su WC, Jeng KS, & Lai MM (2010) Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication. The EMBO Journal 29: 3879–3890
- Lin S, Naim HY, Rodriguez AC, & Roth MG (1998) Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cells. The Journal of cell biology 142: 51–57
- Liu D, Liu X, Yan J, Liu W-J, & Gao GF (2009) Interspecies transmission and host restriction of avian H5N1 influenza virus. Science in China. Series C, Life sciences / Chinese Academy of Sciences 52: 428–438
- Liu H, Golebiewski L, Dow EC, Krug RM, Javier RT, & Rice AP (2010) The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. Journal of virology 84: 11164–11174
- Liu SY, Sanchez DJ, & Cheng G (2011) New developments in the induction and antiviral effectors of type I interferon. Current opinion in immunology 23: 57–64
- Liu T, Muller J, & Ye Z (2002) Association of Influenza Virus Matrix Protein with Ribonucleoproteins May Control Viral Growth and Morphology. Virology 304: 89–96
- Lu X, Masic A, Li Y, Shin Y, Liu Q, & Zhou Y (2010) The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1. The Journal of general virology 91: 1439–1449
- Lu Y, Qian XY, & Krug RM (1994) The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. Genes & development 8: 1817–1828
- Lu Y, Wambach M, Katze MG, & Krug RM (1995) Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor. Virology 214: 222–228
- Ludwig S (2011) Disruption of virus-host cell interactions and cell signaling pathways as an anti-viral approach against influenza virus infections. Biological chemistry 392: 837–847
- Ludwig S, Ehrhardt C, Neumeier ER, Kracht M, Rapp UR, & Pleschka S (2001) Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway. The Journal of biological chemistry 276: 10990–10998
- Luig C, Köther K, Dudek SE, Gaestel M, Hiscott J, Wixler V, & Ludwig S (2010) MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24: 4068–4077
- Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, & Flavell R a (2004) Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proceedings of the National Academy of Sciences of the United States of America 101: 5598–5603
- Luo GX, Luytjes W, Enami M, & Palese P (1991) The polyadenylation signal of influenza virus RNA involves a stretch of uridines followed by the RNA duplex of the panhandle structure. Journal of virology 65: 2861–2867
- Ma K, Roy AM, & Whittaker GR (2001) Nuclear export of influenza virus ribonucleoproteins: identification of an export intermediate at the nuclear periphery. Virology 282: 215–220
- Madshus IH & Stang E (2009) Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking. Journal of cell science 122: 3433–3439
- Mahmoudian S, Auerochs S, Gröne M, & Marschall M (2009) Influenza A virus proteins PB1 and NS1 are subject to functionally important phosphorylation by protein kinase C. The Journal of general virology 90: 1392–1397
- Malakhov MP, Aschenbrenner LM, Smee DF, Wandersee MK, Sidwell RW, Gubareva L V, Mishin VP, Hayden FG, Kim DH, Ing A, Campbell ER, Yu M, & Fang F (2006) Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection. Antimicrobial agents and chemotherapy 50: 1470–1479
- Marión RM, Fortes P, Beloso A, Dotti C, & Ortín J (1999) A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. Molecular and cellular biology 19: 2212–2219
- Marión RM, Zürcher T, De la Luna S, & Ortín J (1997) Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo. The Journal of general virology 78 ( Pt 10: 2447–2451
- Marjuki H, Alam MI, Ehrhardt C, Wagner R, Planz O, Klenk H-D, Ludwig S, & Pleschka S (2006) Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling. The Journal of biological chemistry 281: 16707–16715
- Marjuki H, Gornitzky A, Marathe BM, Ilyushina NA, Aldridge JR, Desai G, Webby RJ, & Webster RG (2011) Influenza A virus-induced early activation of ERK and PI3K mediates V-ATPase-dependent intracellular pH change required for fusion. Cellular microbiology 13: 587–601
- Marjuki H, Yen H-L, Franks J, Webster RG, Pleschka S, & Hoffmann E (2007) Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade. Virology journal 4: 134
- Marsolais D, Hahm B, Walsh KB, Edelmann KH, McGavern D, Hatta Y, Kawaoka Y, Rosen H, & Oldstone MBA (2009) A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proceedings of the National Academy of Sciences of the United States of America 106: 1560–1565
- Martin K & Helenius A (1991a) Transport of incoming influenza virus nucleocapsids into the nucleus. Journal of virology 65: 232–244
- Martin K & Helenius A (1991b) Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import. Cell 67: 117–130
- Maruoka S, Hashimoto S, Gon Y, Nishitoh H, Takeshita I, Asai Y, Mizumura K, Shimizu K, Ichijo H, & Horie T (2003) ASK1 regulates influenza virus infection-induced apoptotic cell death. Biochemical and biophysical research communications 307: 870–876
- Matlin KS, Reggio H, Helenius A, & Simons K (1981) Infectious entry pathway of influenza virus in a canine kidney cell line. The Journal of cell biology 91: 601–613
- Matrosovich M, Tuzikov A, Bovin N, Gambaryan A, Klimov A, Castrucci MR, Donatelli I, & Kawaoka Y (2000) Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals. Journal of virology 74: 8502–8512
- Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, & Klenk H-D (2004) Human and avian influenza viruses target different cell types in cultures of human airway epithelium. Proceedings of the National Academy of Sciences of the United States of America 101: 4620–4624
- Mayer D, Molawi K, Martínez-Sobrido L, Ghanem A, Thomas S, Baginsky S, Grossmann J, García-Sastre A, & Schwemmle M (2007) Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches. Journal of proteome research 6: 672–682
- Mazur I, Anhlan D, Mitzner D, Wixler L, Schubert U, & Ludwig S (2008) The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein. Cellular microbiology 10: 1140–1152
- Mazur I, Wurzer WJ, Ehrhardt C, Pleschka S, Puthavathana P, Silberzahn T, Wolff T, Planz O, & Ludwig S (2007) Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity. Cellular microbiology 9: 1683–1694
- McAuley JL, Chipuk JE, Boyd KL, Van De Velde N, Green DR, & McCullers JA (2010) PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology. PLoS pathogens 6: e1001014
- McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, & McCullers J a (2007) Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell host & microbe 2: 240–249
- McCown MF & Pekosz A (2005) The influenza A virus M2 cytoplasmic tail is required for infectious virus production and efficient genome packaging. Journal of virology 79: 3595–3605
- Melén K, Kinnunen L, Fagerlund R, Ikonen N, Twu KY, Krug RM, & Julkunen I (2007) Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes. Journal of virology 81: 5995–6006
- Mercer J, Schelhaas M, & Helenius A (2010) Virus entry by endocytosis. Annual review of biochemistry 79: 803–833
- Meylan E, Tschopp J, & Karin M (2006) Intracellular pattern recognition receptors in the host response. Nature 442: 39–44
- Mibayashi M, Martínez-Sobrido L, Loo Y-M, Cárdenas WB, Gale M, & García-Sastre A (2007) Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. Journal of virology 81: 514–524
- Min J-Y & Krug RM (2006) The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2’-5' oligo (A) synthetase/RNase L pathway. Proceedings of the National Academy of Sciences of the United States of America 103: 7100–7105
- Min J-Y, Li S, Sen GC, & Krug RM (2007) A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis. Virology 363: 236–243
- Mitzner D, Dudek SE, Studtrucker N, Anhlan D, Mazur I, Wissing J, Jänsch L, Wixler L, Bruns K, Sharma A, Wray V, Henklein P, Ludwig S, & Schubert U (2009) Phosphorylation of the influenza A virus protein PB1-F2 by PKC is crucial for apoptosis promoting functions in monocytes. Cellular microbiology 11: 1502–1516
- Molinari M & Helenius A (2000) Chaperone selection during glycoprotein translocation into the endoplasmic reticulum. Science 288: 331–333
- Momose F, Basler CF, O’Neill RE, Iwamatsu A, Palese P, & Nagata K (2001) Cellular splicing factor RAF-2p48/NPI-5/BAT1/UAP56 interacts with the influenza virus nucleoprotein and enhances viral RNA synthesis. Journal of virology 75: 1899–1908
- Momose F, Handa H, & Nagata K (1996) Identification of host factors that regulate the influenza virus RNA polymerase activity. Biochimie 78: 1103–1108
- Momose F, Kikuchi Y, Komase K, & Morikawa Y (2007) Visualization of microtubule-mediated transport of influenza viral progeny ribonucleoprotein. Microbes and infection / Institut Pasteur 9: 1422–1433
- Momose F, Naito T, Yano K, Sugimoto S, Morikawa Y, & Nagata K (2002) Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis. The Journal of biological chemistry 277: 45306–45314
- Momose F, Sekimoto T, Ohkura T, Jo S, Kawaguchi A, Nagata K, & Morikawa Y (2011) Apical transport of influenza A virus ribonucleoprotein requires Rab11-positive recycling endosome. PloS one 6: e21123
- Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CG, Doering TA, Angelosanto JM, Laidlaw BJ, Yang CY, Sathaliyawala T, Kubota M, Turner D, Diamond JM, Goldrath AW, Farber DL, Collman RG, Wherry EJ, & Artis D (2011) Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nature immunology 12: 1045–1054
- Moore CB, Bergstralh DT, Duncan JA, Lei Y, Morrison TE, Zimmermann AG, Accavitti-Loper MA, Madden VJ, Sun L, Ye Z, Lich JD, Heise MT, Chen Z, & Ting JP (2008) NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451: 573–577
- Mori I, Goshima F, Koshizuka T, Koide N, Sugiyama T, Yoshida T, Yokochi T, Nishiyama Y, & Kimura Y (2003) Differential activation of the c-Jun N-terminal kinase/stress-activated protein kinase and p38 mitogen-activated protein kinase signal transduction pathways in the mouse brain upon infection with neurovirulent influenza A virus. The Journal of general virology 84: 2401–2408
- Morris SJ, Price GE, Barnett JM, Hiscox SA, Smith H, & Sweet C (1999) Role of neuraminidase in influenza virus-induced apoptosis. The Journal of general virology 80 ( Pt 1): 137–146
- Mukaigawa J & Nayak DP (1991) Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2. Journal of virology 65: 245–253
- Munir M (2010) TRIM proteins: another class of viral victims. Science signaling 3: jc2
- Naffakh N, Tomoiu A, Rameix-Welti M-A, & Van der Werf S (2008) Host restriction of avian influenza viruses at the level of the ribonucleoproteins. Annual review of microbiology 62: 403–424
- Nagata K, Kawaguchi A, & Naito T (2008) Host factors for replication and transcription of the influenza virus genome. Reviews in Medical Virology 18: 247–260
- Naito T, Kiyasu Y, Sugiyama K, Kimura A, Nakano R, Matsukage A, & Nagata K (2007a) An influenza virus replicon system in yeast identified Tat-SF1 as a stimulatory host factor for viral RNA synthesis. Proceedings of the National Academy of Sciences of the United States of America 104: 18235–18240
- Naito T, Momose F, Kawaguchi A, & Nagata K (2007b) Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits. Journal of virology 81: 1339–1349
- Nakazawa M, Kadowaki SE, Watanabe I, Kadowaki Y, Takei M, & Fukuda H (2008) PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral research 78: 194–201
- Nakielny S & Dreyfuss G (1999) Transport of proteins and RNAs in and out of the nucleus. Cell 99: 677–690
- Nath ST & Nayak DP (1990) Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1). Molecular and cellular biology 10: 4139–4145
- Nayak DP, Balogun RA, Yamada H, Zhou ZH, & Barman S (2009) Influenza virus morphogenesis and budding. Virus research 143: 147–161
- Nayak DP, Hui EK, & Barman S (2004) Assembly and budding of influenza virus. Virus Research 106: 147–165
- Nemeroff M, Barabino S, Li Y, Keller W, & Krug R (1998) Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3’end formation of cellular pre-mRNAs. Molecular cell 1: 991–1000
- Neumann G, Brownlee GG, Fodor E, & Kawaoka Y (2004) Orthomyxovirus replication, transcription, and polyadenylation. Current topics in microbiology and immunology 283: 121–143
- Neumann G, Castrucci MR, & Kawaoka Y (1997) Nuclear import and export of influenza virus nucleoprotein. Journal of virology 71: 9690–9700
- Neumann G, Hughes MT, & Kawaoka Y (2000) Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1. The EMBO journal 19: 6751–6758
- Nguyen HT, Fry AM, & Gubareva L V (2012) Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods. Antiviral therapy 17: 159–173
- Nicholls JM, Chan MCW, Chan WY, Wong HK, Cheung CY, Kwong DLW, Wong MP, Chui WH, Poon LLM, Tsao SW, Guan Y, & Peiris JSM (2007) Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract. Nature medicine 13: 147–149
- Nicholls JM, Chan RW, Russell RJ, Air GM, & Peiris J (2008) Evolving complexities of influenza virus and its receptors. Trends in microbiology 16: 149–157
- Nieto A, De la Luna S, Bárcena J, Portela A, & Ortín J (1994) Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit. The Journal of general virology 75 ( Pt 1): 29–36
- Noah D, Twu K, & Krug R (2003) Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS. Virology 307: 386–395
- Nunes-Correia I, Eulálio A, Nir S, & Pedroso de Lima MC (2004) Caveolae as an additional route for influenza virus endocytosis in MDCK cells. Cellular & molecular biology letters 9: 47–60
- Obenauer JC, Denson J, Mehta PK, Su X, Mukatira S, Finkelstein DB, Xu X, Wang J, Ma J, Fan Y, Rakestraw KM, Webster RG, Hoffmann E, Krauss S, Zheng J, Zhang Z, & Naeve CW (2006) Large-scale sequence analysis of avian influenza isolates. Science (New York, N.Y.) 311: 1576–1580
- Ohkura N & Sakaguchi S (2009) A novel modifier of regulatory T cells. Nature immunology 10: 685–686
- Okumura Y, Takahashi E, Yano M, Ohuchi M, Daidoji T, Nakaya T, Böttcher E, Garten W, Klenk HD, & Kido H (2010) Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. Journal of virology 84: 5089–5096
- Okuno Y, Matsumoto K, Isegawa Y, & Ueda S (1994) Protection against the mouse-adapted A/FM/1/47 strain of influenza A virus in mice by a monoclonal antibody with cross-neutralizing activity among H1 and H2 strains. Journal of virology 68: 517–520
- Olschläger V, Pleschka S, Fischer T, Rziha H-J, Wurzer W, Stitz L, Rapp UR, Ludwig S, & Planz O (2004) Lung-specific expression of active Raf kinase results in increased mortality of influenza A virus-infected mice. Oncogene 23: 6639–6646
- Opitz B, Rejaibi A, Dauber B, Eckhard J, Vinzing M, Schmeck B, Hippenstiel S, Suttorp N, & Wolff T (2007) IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein. Cellular microbiology 9: 930–938
- O’Neill R, Jaskunas R, Blobel G, Palese P, & Moroianu J (1995) Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import. The Journal of biological chemistry 270: 22701–22704
- O’Neill R & Palese P (1995) NPI-1, the human homolog of SRP-1, interacts with influenza virus nucleoprotein. Virology 206: 116–125
- O’Neill R, Talon J, & Palese P (1998) The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins. The EMBO journal 17: 288–296
- Pal S, Rosas JM, & Rosas-Acosta G (2010) Identification of the non-structural influenza A viral protein NS1A as a bona fide target of the Small Ubiquitin-like MOdifier by the use of dicistronic expression constructs. Journal of virological methods 163: 498–504
- Pal S, Santos A, Rosas JM, Ortiz-Guzman J, & Rosas-Acosta G (2011) Influenza A virus interacts extensively with the cellular SUMOylation system during infection. Virus research 158: 12–27
- Pang IK & Iwasaki A (2011) Inflammasomes as mediators of immunity against influenza virus. Trends in immunology 32: 34–41
- Park C-J (2003) Solution structure of the influenza A virus cRNA promoter: implications for differential recognition of viral promoter structures by RNA-dependent RNA polymerase. Nucleic Acids Research 31: 2824–2832
- Park Y & Katze M (1995) Translational control by influenza virus. Identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translation. The Journal of biological chemistry 270: 28433–28439
- Park YW, Wilusz J, & Katze MG (1999) Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1. Proceedings of the National Academy of Sciences of the United States of America 96: 6694–6699
- Paterson D & Fodor E (2012) Emerging roles for the influenza A virus nuclear export protein (NEP). PLoS pathogens 8: e1003019
- Pauli E-K, Schmolke M, Wolff T, Viemann D, Roth J, Bode JG, & Ludwig S (2008) Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS pathogens 4: e1000196
- Peiris JS, Cheung CY, Leung CY, & Nicholls JM (2009) Innate immune responses to influenza A H5N1: friend or foe? Trends in immunology 30: 574–584
- Perez D & Donis R (1998) The matrix 1 protein of influenza A virus inhibits the transcriptase activity of a model influenza reporter genome in vivo. Virology 249: 52–61
- Perez JT, Varble A, Sachidanandam R, Zlatev I, Manoharan M, García-Sastre A, & TenOever B (2010) Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proceedings of the National Academy of Sciences of the United States of America 107: 11525–11530
- Perez JT, Zlatev I, Aggarwal S, Subramanian S, Sachidanandam R, Kim B, Manoharan M, & Tenoever BR (2012) A Small RNA Enhancer of Viral Polymerase Activity. Journal of virology 86: 13475–13485
- Pichlmair A, Schulz O, Tan CP, Näslund TI, Liljeström P, Weber F, & Reis e Sousa C (2006) RIG-I-mediated antiviral responses to single-stranded RNA bearing 5’-phosphates. Science (New York, N.Y.) 314: 997–1001
- Pirhonen J, Sareneva T, Kurimoto M, Julkunen I, & Matikainen S (1999) Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. Journal of immunology (Baltimore, Md. : 1950) 162: 7322–7329
- Pleschka S (2008) RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade. Biological chemistry 389: 1273–1282
- Pleschka S, Wolff T, Ehrhardt C, Hobom G, Planz O, Rapp UR, & Ludwig S (2001) Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nature cell biology 3: 301–305
- Poon LL, Pritlove DC, Fodor E, & Brownlee GG (1999) Direct evidence that the poly(A) tail of influenza A virus mRNA is synthesized by reiterative copying of a U track in the virion RNA template. Journal of virology 73: 3473–3476
- Portela A & Digard P (2002) The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication. The Journal of general virology 83: 723–734
- Privalsky ML & Penhoet EE (1981) The structure and synthesis of influenza virus phosphoproteins. The Journal of biological chemistry 256: 5368–5376
- Pérez-González A, Rodriguez A, Huarte M, Salanueva IJ, & Nieto A (2006) hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. Journal of molecular biology 362: 887–900
- Qian XY, Alonso-Caplen F, & Krug RM (1994) Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA. Journal of virology 68: 2433–2441
- Qiu Y, Nemeroff M, & Krug RM (1995) The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing. RNA (New York, N.Y.) 1: 304–316
- Qiu YUN & Krug RM (1994) The influenza virus NS1 protein is a poly (A) -binding protein that inhibits nuclear export of mRNAs containing poly (A). journal of virology 68: 2425–2432
- Read EKC & Digard P (2010) Individual influenza A virus mRNAs show differential dependence on cellular NXF1 / TAP for their nuclear export. Journal of General Virology 91: 1290–1301
- Reinhardt J & Wolff T (2000) The influenza A virus M1 protein interacts with the cellular receptor of activated C kinase (RACK) 1 and can be phosphorylated by protein kinase C. Veterinary microbiology 74: 87–100
- Resa-infante P, Jorba N, Coloma R, & Ortin J (2011) The influenza virus RNA synthesis machine: advances in its structure and function. RNA Biology 8: 207–215
- Resa-Infante P, Jorba N, Zamarreño N, Fernández Y, Juárez S, & Ortín J (2008) The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication. PloS one 3: e3904
- Richardson JC, Sciences B, & Collins F (1991) NS2 protein of influenza virus is found in purified virus and phosphorylated in infected cells. Archivies of Virology 116: 69–80
- Rider TH, Zook CE, Boettcher TL, Wick ST, Pancoast JS, & Zusman BD (2011) Broad-spectrum antiviral therapeutics. PLoS ONE 6: e22572
- Riner A, Chan-Tack KM, & Murray JS (2009) Original research: Intravenous ribavirin--review of the FDA’s Emergency Investigational New Drug Database (1997-2008) and literature review. Postgraduate medicine 121: 139–146
- Robb NC, Smith M, Vreede FT, & Fodor E (2009) NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. The Journal of general virology 90: 1398–1407
- Roberts PC & Compans RW (1998) Host cell dependence of viral morphology. Proceedings of the National Academy of Sciences of the United States of America 95: 5746–5751
- Robertson JS, Schubert M, & Lazzarini RA (1981) Polyadenylation sites for influenza virus mRNA. Journal of virology 38: 157–163
- Rogers GN & Paulson JC (1983) Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. Virology 127: 361–373
- Rosen H & Goetzl EJ (2005) Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nature reviews. Immunology 5: 560–570
- Rossman JS, Jing X, Leser GP, & Lamb RA (2010) Influenza virus M2 protein mediates ESCRT-independent membrane scission. Cell 142: 902–913
- Rossman JS & Lamb RA (2009) Autophagy, apoptosis, and the influenza virus M2 protein. Cell host & microbe 6: 299–300
- Rossman JS, Leser GP, & Lamb RA (2012) Filamentous Influenza Virus Enters Cells via Macropinocytosis. Journal of virology 86: 10950–10960
- Roy CR, Salcedo SP, & Gorvel J-P (2006) Pathogen-endoplasmic-reticulum interactions: in through the out door. Nature reviews. Immunology 6: 136–147
- Ruigrok RW, Barge A, Durrer P, Brunner J, Ma K, & Whittaker GR (2000) Membrane interaction of influenza virus M1 protein. Virology 267: 289–298
- Rust MJ, Lakadamyali M, Zhang F, & Zhuang X (2004) Assembly of endocytic machinery around individual influenza viruses during viral entry. Nature structural & molecular biology 11: 567–573
- Saito T & Kawano K (1997) Loss of glycosylation at Asn144 alters the substrate preference of the N8 influenza A virus neuraminidase. The Journal of veterinary medical science / the Japanese Society of Veterinary Science 59: 923–926
- Saito T, Taylor G, & Webster RG (1995) Steps in maturation of influenza A virus neuraminidase. Journal of virology 69: 5011–5017
- Salom D, Hill BR, Lear JD, & DeGrado WF (2000) pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry 39: 14160–14170
- Salvatore M, Basler CF, Parisien JP, Horvath CM, Bourmakina S, Zheng H, Muster T, Palese P, & García-Sastre A (2002) Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis. Journal of virology 76: 1206–1212
- Sanz-Ezquerro JJ, Fernández Santarén J, Sierra T, Aragón T, Ortega J, Ortín J, Smith GL, & Nieto A (1998) The PA influenza virus polymerase subunit is a phosphorylated protein. The Journal of general virology 79 ( Pt 3): 471–478
- Satterly N, Tsai P-L, Van Deursen J, Nussenzveig DR, Wang Y, Faria P a, Levay A, Levy DE, & Fontoura BM a (2007) Influenza virus targets the mRNA export machinery and the nuclear pore complex. Proceedings of the National Academy of Sciences of the United States of America 104: 1853–1858
- Scheiffele P, Roth M, & Simons K (1997) Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. The EMBO journal 16: 5501–5508
- Schmitt AP & Lamb RA (2004) Escaping from the cell: assembly and budding of negative-strand RNA viruses. Current topics in microbiology and immunology 283: 145–196
- Schneider J & Wolff T (2009) Nuclear functions of the influenza A and B viruses NS1 proteins: do they play a role in viral mRNA export? Vaccine 27: 6312–6316
- Schneider RJ & Mohr I (2003) Translation initiation and viral tricks. Trends in Biochemical Sciences 28: 130–136
- Schroder K & Tschopp J (2010) The inflammasomes. Cell 140: 821–832
- Schroeder C, Heider H, Möncke-Buchner E, & Lin T-I (2005) The influenza virus ion channel and maturation cofactor M2 is a cholesterol-binding protein. European biophysics journal : EBJ 34: 52–66
- Schultz-Cherry S & Hinshaw V (1996) Influenza virus neuraminidase activates latent transforming growth factor beta. Journal of virology 70: 8624–8629
- Scott I (2010) The role of mitochondria in the mammalian antiviral defense system. Mitochondrion 10: 316–320
- Scull MA & Rice CM (2010) A big role for small RNAs in influenza virus replication. Proceedings of the National Academy of Sciences of the United States of America 107: 11153–11154
- Service RF (1997) Researchers seek new weapon against the flu. Science (New York, N.Y.) 275: 756–757
- Shapira SD, Gat-Viks I, Shum BO, Dricot A, De Grace MM, Wu L, Gupta PB, Hao T, Silver SJ, Root DE, Hill DE, Regev A, & Hacohen N (2009) A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell 139: 1255–1267
- Shapiro GI, Gurney T, & Krug RM (1987) Influenza virus gene expression: control mechanisms at early and late times of infection and nuclear-cytoplasmic transport of virus-specific RNAs. Journal of virology 61: 764–773
- Sharma M, Yi M, Dong H, Qin H, Peterson E, Busath DD, Zhou HX, & Cross TA (2010) Insight into the mechanism of the influenza A proton channel from a structure in a lipid bilayer. Science (New York, N.Y.) 330: 509–512
- Shimizu K, Iguchi A, Gomyou R, & Ono Y (1999) Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site. Virology 254: 213–219
- Shimizu T, Takizawa N, Watanabe K, Nagata K, & Kobayashi N (2011) Crucial role of the influenza virus NS2 (NEP) C-terminal domain in M1 binding and nuclear export of vRNP. FEBS letters 585: 41–46
- Shin Y-K, Li Y, Liu Q, Anderson DH, Babiuk LA, & Zhou Y (2007a) SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation. Journal of virology 81: 12730–12739
- Shin Y-K, Liu Q, Tikoo SK, Babiuk L a, & Zhou Y (2007b) Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation. The Journal of general virology 88: 942–950
- Shin Y-K, Liu Q, Tikoo SK, Babiuk LA, & Zhou Y (2007c) Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K. The Journal of general virology 88: 13–18
- Shinya K, Ebina M, Yamada S, Ono M, Kasai N, & Kawaoka Y (2006) Avian flu: influenza virus receptors in the human airway. Nature 440: 435–436
- Sieczkarski SB, Brown HA, & Whittaker GR (2003) Role of Protein Kinase C  II in Influenza Virus Entry via Late Endosomes. Journal of virology 77: 460–469
- Sieczkarski SB & Whittaker GR (2002) Influenza virus can enter and infect cells in the absence of clathrin-mediated endocytosis. Journal of virology 76: 10455–10464
- Sieczkarski SB & Whittaker GR (2003) Differential requirements of Rab5 and Rab7 for endocytosis of influenza and other enveloped viruses. Traffic (Copenhagen, Denmark) 4: 333–343
- Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, & Steinmetzer T (2011) Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorganic & medicinal chemistry letters 21: 4860–4864
- Skehel JJ & Wiley DC (2000) Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annual review of biochemistry 69: 531–569
- Sleeman K, Mishin VP, Deyde VM, Furuta Y, Klimov AI, & Gubareva L V (2010) In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 A(H1N1) viruses. Antimicrobial agents and chemotherapy 54: 2517–2524
- Smith AM, Adler FR, McAuley JL, Gutenkunst RN, Ribeiro RM, McCullers JA, & Perelson AS (2011) Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics. PLoS computational biology 7: e1001081
- Soubies SM, Volmer C, Croville G, Loupias J, Peralta B, Costes P, Lacroux C, Guérin J-L, & Volmer R (2010) Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence. Journal of virology 84: 6733–6747
- Staeheli P, Haller O, Boll W, Lindenmann J, & Weissmann C (1986) Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell 44: 147–158
- Starko KM (2009) Salicylates and pandemic influenza mortality, 1918-1919 pharmacology, pathology, and historic evidence. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 49: 1405–1410
- Stasakova J, Ferko B, Kittel C, Sereinig S, Romanova J, Katinger H, & Egorov A (2005) Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18. The Journal of general virology 86: 185–195
- Steinhauer DA, Wharton SA, Wiley DC, & Skehel JJ (1991) Deacylation of the hemagglutinin of influenza A/Aichi/2/68 has no effect on membrane fusion properties. Virology 184: 445–448
- Stieneke-Gröber A, Vey M, Angliker H, Shaw E, Thomas G, Roberts C, Klenk HD, & Garten W (1992) Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease. The EMBO journal 11: 2407–2414
- Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, & DeGrado WF (2008) Structural basis for the function and inhibition of an influenza virus proton channel. Nature 451: 596–599
- Strambio-De-Castillia C, Niepel M, & Rout MP (2010) The nuclear pore complex: bridging nuclear transport and gene regulation. Nature reviews. Molecular cell biology 11: 490–501
- Su C-Y, Cheng T-JR, Lin M-I, Wang S-Y, Huang W-I, Lin-Chu S-Y, Chen Y-H, Wu C-Y, Lai MMC, Cheng W-C, Wu Y-T, Tsai M-D, Cheng Y-SE, & Wong C-H (2010) High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity. Proceedings of the National Academy of Sciences of the United States of America 107: 19151–19156
- Sugrue RJ, Belshe R, & AJ H (1990) Palmitoylation of the influenza A virus M2 protein. virology 179: 51–56
- Sui J, Hwang WC, Perez S, Wei G, Aird D, Chen LM, Santelli E, Stec B, Cadwell G, Ali M, Wan H, Murakami A, Yammanuru A, Han T, Cox NJ, Bankston LA, Donis RO, Liddington RC, & Marasco WA (2009) Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nature structural & molecular biology 16: 265–273
- Sun E, He J, & Zhuang X (2013) Dissecting the Role of COPI Complexes in Influenza Virus Infection. Journal of virology 87: 2673–2685
- Sun X & Whittaker GR (2007) Role of the actin cytoskeleton during influenza virus internalization into polarized epithelial cells. Cellular microbiology 9: 1672–1682
- Suzuki T, Takahashi T, Guo C, Hidari K, Miyamoto D, Goto H, Kawaoka Y, & Suzuki Y (2005) Sialidase Activity of Influenza A Virus in an Endocytic Pathway Enhances Viral Replication. Journal of virology 79: 11705–11715
- Suzuki T, Takahashi T, Nishinaka D, Murakami M, Fujii S, Hidari K, Miyamoto D, Li Y, & Suzuki Y (2003) Inhibition of influenza A virus sialidase activity by sulfatide. FEBS Letters 553: 355–359
- Szegezdi E, Logue SE, Gorman AM, & Samali A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO reports 7: 880–885
- Szul T & Sztul E (2011) COPII and COPI Traffic at the ER-Golgi Interface. Physiology (Bethesda, Md.) 26: 348–364
- Takahashi T, Murakami K, Nagakura M, Kishita H, Watanabe S, Honke K, Ogura K, Tai T, Kawasaki K, Miyamoto D, Hidari KIPJ, Guo CT, Suzuki Y, & Suzuki T (2008) Sulfatide is required for efficient replication of influenza A virus. Journal of virology 82: 5940–5950
- Takahashi T, Satoh H, Takaguchi M, Takafuji S, Yokoyama H, Fujii S, & Suzuki T (2010) Binding of sulphatide to recombinant haemagglutinin of influenza A virus produced by a baculovirus protein expression system. Journal of biochemistry 147: 459–462
- Takeda M, Leser GP, Russell CJ, & Lamb RA (2003) Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion. Proceedings of the National Academy of Sciences of the United States of America 100: 14610–14617
- Tamura M, Webster RG, & Ennis FA (1993) Neutralization and infection-enhancement epitopes of influenza A virus hemagglutinin. Journal of immunology (Baltimore, Md. : 1950) 151: 1731–1738
- Tan SL & Katze MG (1998) Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 18: 757–766
- Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, & Wang C (2010) Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein. Journal of immunology (Baltimore, Md. : 1950) 184: 5777–5790
- Tatu U, Hammond C, & Helenius A (1995) Folding and oligomerization of influenza hemagglutinin in the ER and the intermediate compartment. The EMBO journal 14: 1340–1348
- Thomas JM, Stevens MP, Percy N, & Barclay WS (1998) Phosphorylation of the M2 protein of influenza A virus is not essential for virus viability. Virology 252: 54–64
- Thomas M, Kranjec C, Nagasaka K, Matlashewski G, & Banks L (2011) Analysis of the PDZ binding specificities of Influenza A virus NS1 proteins. Virology journal 8: 25
- Thomas PG, Dash P, Aldridge JR, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, & Kanneganti T (2009) The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30: 566–575
- Triana-Baltzer GB, Babizki M, Chan MC, Wong AC, Aschenbrenner LM, Campbell ER, Li QX, Chan RW, Peiris JS, Nicholls JM, & Fang F (2010) DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis. The Journal of antimicrobial chemotherapy 65: 275–284
- Triana-Baltzer GB, Gubareva L V, Klimov AI, Wurtman DF, Moss RB, Hedlund M, Larson JL, Belshe RB, & Fang F (2009a) Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PloS one 4: e7838
- Triana-Baltzer GB, Gubareva L V, Nicholls JM, Pearce MB, Mishin VP, Belser JA, Chen L-M, Chan RWY, Chan MCW, Hedlund M, Larson JL, Moss RB, Katz JM, Tumpey TM, & Fang F (2009b) Novel pandemic influenza A(H1N1) viruses are potently inhibited by DAS181, a sialidase fusion protein. PloS one 4: e7788
- Tschopp J & Schroder K (2010) NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nature Reviews Immunology 10: 210–215
- Turan K, Mibayashi M, Sugiyama K, Saito S, Numajiri A, & Nagata K (2004) Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. Nucleic acids research 32: 643–652
- Twu KY, Noah DL, Rao P, Kuo R, & Krug RM (2006) The CPSF30 Binding Site on the NS1A Protein of Influenza A Virus Is a Potential Antiviral Target. Journal of virology 80: 3957–3965
- Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O’Sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, & Holtzman MJ (2005) CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection. Nature medicine 11: 1180–1187
- Ueda M, Daidoji T, Du A, Yang CS, Ibrahim MS, Ikuta K, & Nakaya T (2010) Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells. Journal of virology 84: 3068–3078
- Ulmanen I, Broni BA, & Krug RM (1981) Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription. Proceedings of the National Academy of Sciences of the United States of America 78: 7355–7359
- Vanderlinden E, Göktas F, Cesur Z, Froeyen M, Reed ML, Russell CJ, Cesur N, & Naesens L (2010) Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin. Journal of virology 84: 4277–4288
- Varga ZT, Ramos I, Hai R, Schmolke M, García-Sastre A, Fernandez-Sesma A, & Palese P (2011) The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein. PLoS pathogens 7: e1002067
- Varki NM & Varki A (2007) Diversity in cell surface sialic acid presentations: implications for biology and disease. Laboratory investigation; a journal of technical methods and pathology 87: 851–857
- Veit M (2012) Palmitoylation of virus proteins. Biology of the cell / under the auspices of the European Cell Biology Organization 104: 493–515
- Veit M, Klenk HD, Kendal A, & Rott R (1991a) The M2 protein of influenza A virus is acylated. The Journal of general virology 72 (Pt 6): 1461–1465
- Veit M, Kretzschmar E, Kuroda K, Garten W, Schmidt MF, Klenk HD, & Rott R (1991b) Site-specific mutagenesis identifies three cysteine residues in the cytoplasmic tail as acylation sites of influenza virus hemagglutinin. Journal of virology 65: 2491–2500
- Veit M & Schmidt MF (1993) Timing of palmitoylation of influenza virus hemagglutinin. FEBS letters 336: 243–247
- Virelizier JL (1975) Host defenses against influenza virus: the role of anti-hemagglutinin antibody. Journal of immunology (Baltimore, Md. : 1950) 115: 434–439
- Vreede FT, Jung TE, & Brownlee GG (2004) Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates. Journal of virology 78: 9568–9572
- De Vries E, Tscherne DM, Wienholts MJ, Cobos-Jiménez V, Scholte F, García-Sastre A, Rottier PJ, & De Haan CA (2011) Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway. PLoS pathogens 7: e1001329
- Wagner R, Matrosovich M, & Klenk H-D (2002) Functional balance between haemagglutinin and neuraminidase in influenza virus infections. Reviews in medical virology 12: 159–166
- Waheed AA & Freed EO (2007) Influenza virus not cRAFTy enough to dodge viperin. Cell host & microbe 2: 71–72
- Walkiewicz MP, Basu D, Jablonski JJ, Geysen HM, & Engel D a (2011) Novel inhibitor of influenza non-structural protein 1 blocks multi-cycle replication in an RNase L-dependent manner. The Journal of general virology 92: 60–70
- Walsh KB, Teijaro JR, Wilker PR, Jatzek A, Fremgen DM, Das SC, Watanabe T, Hatta M, Shinya K, Suresh M, Kawaoka Y, Rosen H, & Oldstone MBA (2011) Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. Proceedings of the National Academy of Sciences of the United States of America 108: 12018–12023
- Wang P, Palese P, & O’Neill R (1997) The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus nucleoprotein NP is a nonconventional nuclear localization signal. Journal of virology 71: 1850–1856
- Wang TT & Palese P (2009) Universal epitopes of influenza virus hemagglutinins ? Nature structural & molecular biology 16: 233–234
- Wang W, Cui Z-Q, Han H, Zhang Z-P, Wei H-P, Zhou Y-F, Chen Z, & Zhang X-E (2008) Imaging and characterizing influenza A virus mRNA transport in living cells. Nucleic acids research 36: 4913–4928
- Wang W & Krug RM (1998) U6atac snRNA, the highly divergent counterpart of U6 snRNA, is the specific target that mediates inhibition of AT-AC splicing by the influenza virus NS1 protein. RNA (New York, N.Y.) 4: 55–64
- Wang X, Hinson ER, & Cresswell P (2007) The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell host & microbe 2: 96–105
- Wang Y, Landman B, Wu C, Gelb J, & Golovan S (2013) Comparison of vRNA and cRNA based reporters for detection of influenza replication. Antiviral research 98: 76–84
- Watanabe K, Fuse T, Asano I, Tsukahara F, Maru Y, Nagata K, Kitazato K, & Kobayashi N (2006) Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus life cycle. FEBS letters 580: 5785–5790
- Watanabe K, Takizawa N, Katoh M, Hoshida K, Kobayashi N, & Nagata K (2001) Inhibition of nuclear export of ribonucleoprotein complexes of influenza virus by leptomycin B. Virus research 77: 31–42
- Watanabe R & Lamb RA (2010) Influenza virus budding does not require a functional AAA+ ATPase, VPS4. Virus research 153: 58–63
- Watanabe R, Leser GP, & Lamb RA (2011) Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin. Virology 417: 50–56
- Weber F, Kochs G, Gruber S, & Haller O (1998) A classical bipartite nuclear localization signal on Thogoto and influenza A virus nucleoproteins. Virology 250: 9–18
- Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, & Korsmeyer SJ (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes & development 14: 2060–2071
- Whittaker G, Bui M, & Helenius A (1996) Nuclear trafficking of influenza virus ribonuleoproteins in heterokaryons. Journal of virology 70: 2743–2756
- Whittaker G, Kemler I, & Helenius A (1995) Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus. Journal of virology 69: 439–445
- Wisskirchen C, Ludersdorfer TH, Müller DA, Moritz E, & Pavlovic J (2011) The cellular RNA helicase UAP56 is required for prevention of double-stranded RNA formation during influenza A virus infection. Journal of virology 85: 8646–8655
- Wolff T, O’Neill R, & Palese P (1998) NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells. Journal of virology 72: 7170–7180
- Woods JM, Bethell RC, Coates JA, Healy N, Hiscox SA, Pearson BA, Ryan DM, Ticehurst J, Tilling J, & Walcott SM (1993) 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro. Antimicrobial agents and chemotherapy 37: 1473–1479
- Wu C-Y, Jeng K-S, & Lai MM-C (2011) The SUMOylation of matrix protein M1 modulates the assembly and morphogenesis of influenza A virus. Journal of virology 85: 6618–6628
- Xu K, Klenk C, Liu B, Keiner B, Cheng J, Zheng B-J, Li L, Han Q, Wang C, Li T, Chen Z, Shu Y, Liu J, Klenk H-D, & Sun B (2011) Modification of nonstructural protein 1 of influenza A virus by SUMO1. Journal of virology 85: 1086–1098
- Yamada H, Chounan R, Higashi Y, Kurihara N, & Kido H (2004) Mitochondrial targeting sequence of the influenza A virus PB1-F2 protein and its function in mitochondria. FEBS letters 578: 331–336
- Yan N & Chen ZJ (2012) Intrinsic antiviral immunity. Nature immunology 13: 214–222
- Yankulov K, Todorov I, Romanowski P, Licatalosi D, Cilli K, McCracken S, Laskey R, & Bentley DL (1999) MCM proteins are associated with RNA polymerase II holoenzyme. Molecular and cellular biology 19: 6154–6163
- Yao L, Korteweg C, Hsueh W, & Gu J (2008) Avian influenza receptor expression in H5N1-infected and noninfected human tissues. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22: 733–740
- Yasuda J, Nakada S, Kato A, Toyoda T, & Ishihama A (1993) Molecular assembly of influenza virus: association of the NS2 protein with virion matrix. Virology 196: 249–255
- Yatim N & Albert ML (2011) Dying to replicate: the orchestration of the viral life cycle, cell death pathways, and immunity. Immunity 35: 478–490
- Ye Z, Liu T, Offringa DP, McInnis J, & Levandowski RA (1999) Association of influenza virus matrix protein with ribonucleoproteins. Journal of virology 73: 7467–7473
- Ye Z, Robinson D, & Wagner RR (1995) Nucleus-targeting domain of the matrix protein (M1) of influenza virus. Journal of virology 69: 1964–1970
- Yewdell JW, Taylor A, Yellen A, Caton A, Gerhard W, & Bächi T (1993) Mutations in or near the fusion peptide of the influenza virus hemagglutinin affect an antigenic site in the globular region. Journal of virology 67: 933–942
- Yondola MA, Fernandes F, Belicha-Villanueva A, Uccelini M, Gao Q, Carter C, & Palese P (2011) Budding capability of the influenza virus neuraminidase can be modulated by tetherin. Journal of virology 85: 2480–2491
- Yoshida R, Igarashi M, Ozaki H, Kishida N, Tomabechi D, Kida H, Ito K, & Takada A (2009) Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses. PLoS pathogens 5: e1000350
- Yount JS, Moltedo B, Yang Y-Y, Charron G, Moran TM, López CB, & Hang HC (2010) Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3. Nature chemical biology 6: 610–614
- Yu M, Liu X, Cao S, Zhao Z, Zhang K, Xie Q, Chen C, Gao S, Bi Y, Sun L, Ye X, Gao GF, & Liu W (2012) Identification and characterization of three novel nuclear export signals in the influenza A virus nucleoprotein. Journal of virology 86: 4970–4980
- Yángüez E, Castello A, Welnowska E, Carrasco L, Goodfellow I, & Nieto A (2011) Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation. Virology 413: 93–102
- Yángüez E, Rodriguez P, Goodfellow I, & Nieto A (2012) Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation. Virology 422: 297–307
- Zamarin D, García-Sastre A, Xiao X, Wang R, & Palese P (2005) Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS pathogens 1: e4
- Zamarin D, Ortigoza MB, & Palese P (2006) Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice. Journal of virology 80: 7976–7983
- Van Zeijl M & Matlin K (1990) Microtubule perturbation inhibits intracellular transport of an apical membrane glycoprotein in a canine kidney epithelial cells. Cell regulation 1: 921–936
- Zhang J & Lamb R (1996) Characterization of the membrane association of the influenza virus matrix protein in living cells. Virology 225: 255–266
- Zhang J, Li G, & Ye X (2010) Cyclin T1/CDK9 interacts with influenza A virus polymerase and facilitates its association with cellular RNA polymerase II. Journal of virology 84: 12619–12627
- Zhang J, Pekosz A, Lamb RA, & Zhang JIE (2000) Influenza Virus Assembly and Lipid Raft Microdomains : a Role for the Cytoplasmic Tails of the Spike Glycoproteins. Journal of virology 74: 4634–4644
- Zhao C, Hsiang TY, Kuo RL, & Krug RM (2010) ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. Proceedings of the National Academy of Sciences of the United States of America 107: 2253–2258
- Zhirnov OP & Klenk H-D (2007) Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. Apoptosis : an international journal on programmed cell death 12: 1419–1432
- Zhirnov OP, Klenk HD, & Wright PF (2011) Aprotinin and similar protease inhibitors as drugs against influenza. Antiviral research 92: 27–36
- Zhirnov OP, Konakova TE, Wolff T, & Klenk H-D (2002) NS1 protein of influenza A virus down-regulates apoptosis. Journal of virology 76: 1617–1625
- Zhirnov OP, Ovcharenko A V, & Bukrinskaya AG (1984) Suppression of influenza virus replication in infected mice by protease inhibitors. The Journal of general virology 65 ( Pt 1): 191–196
- Zhou Z, Jiang X, Liu D, Fan Z, Hu X, Yan J, Wang M, & Gao GF (2009) Autophagy is involved in influenza A virus replication. Autophagy 5: 321–328
- Zielecki F, Semmler I, Kalthoff D, Voss D, Mauel S, Gruber AD, Beer M, & Wolff T (2010) Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein. Journal of virology 84: 10708–10718
- Zou H, Henzel W, Liu X, Lutschg A, & Wang X (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405–413
Book sections
- Palese P, Shaw ML (2007) Orthomyxoviridae: The Viruses and Their Replication. In Fields Virology, Fifth Edition, Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (eds), Vol. 2, 47, pp 1647-1689. Philadelphia: Wolters Kluwer; Lippincott Williams & Wilkins
- Wright PF, Neumann G, Kawaoka Y (2007) Orthomyxoviruses. In Fields Virology, Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (eds), Vol. 2, Fifth Edition edn, 48, pp 1691-1740. Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Kong, Sydney, Tokyo: Wolters Kluwer; Lippincott Williams & Wilkins